Endocrine Abstracts

Abundant evidence demonstrates that long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous study shows a significant association between IL4 genotypes and T2DM, as well as between IL4 genotypes and the lower circulatory levels of high-density lipoprotein-cholesterol (HDL-C). In addition, IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance as well as being involved in lipid m...

IntroductionDapagliflozin is sub-optimally utilised in the real world. There is a lack of a comprehensive collaborative guidance for a practical approach to manage patients with cardiometabolic, renometabolic and viscerometabolic disorders. Patients across the CRV-M continuum includes patients with varied clinical profiles.MethodsTwo round Delphi study was conducted using a virtual online-digital connect appr...

Introduction: Full blood count (FBC), C-reactive protein (CRP), albumin and serum inflammation-based scores reflect systemic inflammation and predict outcomes in oncological patients. While these are increasingly used in cancer, little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in patients with PAs and investigate the usefulness of such parameters in predicting aggressive/refractory disease.Methods: W...

Background: Adipocyte and osteoblast derive from the same mesenchimal progenitor. Age-related decrease in bone mass is accompanied by an increase in marrow adipose tissue. Vitamin D3 (VD) inhibits adipogenesis in 3T3-L1 preadipocytes. Recently it has been demonstrated that alendronate (ALN) inhibits adipogenesis while promoting osteoblast differentiation of mesenchimal stem cells.Aim of the study: To evaluate the in vitro role of ALN on 3T3-L1 adi...

Recent data suggest that circulating retinol binding protein-4 (RBP4) is involved in the pathogenesis of insulin resistance in rodents and humans. Moreover, protein C inhibitor (PCI) which specifically binds retinoic acid was found to be increased in myocardial infarction survivors who are also insulin-resistant.Therefore, we investigated the association of insulin resistance with plasma retinol binding factors (RBP4 and PCI active antigen) in nondiabeti...

A 34-year-old female was seen in the joint diabetic antenatal clinic during her second pregnancy. She had a very unfortunate first pregnancy, which resulted in a still birth following a traumatic delivery. She also had a large post-partum haemorrhage causing Sheehan’s syndrome. Hormone replacement therapy had been commenced, including hydrocortisone, thyroxine and growth hormone (GH). Pre-treatment quality of life assessment in GH deficient adults score (Qol-AGHDA) 21, an...

Our aim was to evaluate the impact of some clinical (obesity, metabolic syndrome), biochemical (HOMA-IR), histological (fibrosis, necroinflammation, steatosis) and viral factors (HCV viraemia) on both EVR and SVR in patients with genotype 1 chronic hepatitis C (CHC) treated with peginterferon plus ribavirin.Patients and methods: We evaluated retrospectively 188 naïve patients with CHC treated with peginterferon plus ribavirin at standard weight-base...

17α-Hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment of prostatic carcinoma, which is androgen-dependent in the majority of cases. Abiraterone and its analogues have been found strong inhibitors of P45017α suggesting that steroid de...

The discovery of the fundamental involvement of receptor activator for nuclear factor-KB ligand (RANKL) in osteoclast (OC) formation, has enabled the routine generation of human OCs in vitro from human peripheral blood mononuclear cells (PBMCs). Beta C-terminal telopeptide (beta-CTx) is a specific resorption marker for degradation of bone type I collagen by OCs. We have evaluated the correlation between beta-CTx released from dentine wafers on which OC were c...

Introduction: The thyroid is a multifaced endocrine gland. By its hormones it has an effect on almost all organs of the body, metabolism and defence system too. The relationship between the thyroid hormones and the nonspecific defence system has been less studied.Aim: To study and prove whether the endogenous thyroxin (FT4) is involved in the nonspecific defence system of the organism. We followed the correlation between the FT4 and...